478: Nitric Oxide for Preventing and Reversing Heart Disease with Dr. Nathan Bryan

Ashley James & Dr. Nathan Bryan


  • The importance of nitric oxide in our body
  • What is Nitric Oxide Deficiency and its causes
  • What is nitric oxide’s role in our heart health?
  • Why mouthwash could raise the risk of heart disease?
  • How does face cream increase nitric oxide production?
  • What are the two main signs of toxicity of nitric oxide?

Nitric oxide is one of the most important molecules produced in the human body that controls and regulates most cellular functions. In this episode, Dr. Nathan Bryan shares how nitric oxide helps promote proper blood flow, which may improve exercise performance, lower blood pressure, and improve the function of the brain.


Hello, true health seeker and welcome to another exciting episode of the Learn True Health podcast. So this is going to be a fun one. We have an amazing doctor on, Dr. Nathan Bryan. He's over 20 years of experience in studying nitric oxide. I first heard about nitric oxide in my interview with Dr. Essylstyn. When he talks about how he took– I believe 24, 26 patients who are on their deathbeds. The cardiologist said we've given you everything, go home to die. There's nothing we can do for you. Your heart disease is so far gone. Your moments away from death. And Dr. Esselstyn took these people and put them on a whole food plant-based diet. So put them on food that significantly increased the body's nitric oxide, and they all bounced back. It was absolutely amazing. And of course, he went on to publish this and publish other studies and then write his book, How to Reverse and Prevent Heart Disease. 

So when I heard about how he uses certain foods, like leafy greens and balsamic. And you can do some really delicious things or some really delicious balsamic stuff out there. I particularly love this one balsamic and I'm not a fan of that strong vinegar taste but this balsamic doesn't taste like that at all. It has a hint of maple and fig to it and it's so delicious. And you use that to cover your cooked vegetables and your steamed vegetables, which increases nitric oxide. And there are other foods we'll talk about in today's interview, where you will learn how to increase nitric oxide naturally in the body. And why it is the key to preventing and reversing disease and anti-aging.

Now Dr. Nathan Bryan just talks about a product he developed and did. And also developed a few pharmaceuticals that increase nitric oxide that has now, they're doing studies, they're doing trials, and they've saved people's lives in ER. So that is very exciting. Of course, we want to prevent ourselves from ever needing to be in the ER in the first place by increasing nitric oxide naturally. He also developed a way supplement that can help you as well. And he talks about that. He also developed a really interesting skincare line because nitric oxide would put on the skin. It cures things like rosacea and fine lines and wrinkles and helps pushes oxygen into these newly constructed cells. Then they appear younger and healthier and healthier.

And I had this rosacea. My grandmother had it. My mom had some. I always thought it was just part of the women in my family. I've been using the cream and so I love it. It's very high quality and I really like it. So I'm noticing that my rosacea is starting to get better, which I thought was really interesting. So I am noticing now that I'm eating more foods with nitric oxide and knowing I've got more energy. This is great. I can't wait to put it to the test and do some heavy hiking this summer.

But what I have noticed by using his products since I did the interview is I have seen a difference and that's really exciting. And he does say some things that I think are really important to take the heart and share with everyone you love, especially when he talks about certain habits that we have that can decrease your nitric oxide so much that they're significantly important in increasing heart disease. So we want to make sure that none of our friends and family are doing these activities that are noted to decrease nitric oxide in the body, increase heart disease, and shorten people's lifespan. So this will be an episode you want to share with everyone. I've already told so many of my friends. I can't wait for you guys to listen to this episode because if you follow the simple tools he gives you today. The simple lifestyle habits that he gives you today. You're going to increase the nitric oxide and substantially increase the quality and your life as a result. So definitely want to share this with your friends and family.

Thank you so much for being a listener of the show and if you're interested in getting any of his products, including his book, Dr. Nathan Bryan's book. You will go to his website, which is n1o1.com. It's a chemical formula for nitric oxide. So that's N, in the letter N, one, the number one and then the letter O, the number one.com And of course, use the coupon code LTH, that's Learn True Health code. LTH will give you a discount. I made sure that my wonderful listeners were going to get a great discount when they went to the website by Dr. Nathan Bryan's book. Or his nitric oxide-based skincare line or his special supplement, which increases nitric oxide in the body. And of course, the links to everything that Dr. Nathan Bryan does is going to be in the show notes of today's podcast on learntruehealth.com. So come and join the Facebook group so we can talk about all this stuff after you listen to the episode. I can't wait to hear from you guys in the Learn True Health Facebook group. And I'm so grateful that we're here today. To be able to learn together and grow together. So we're on a health journey together on Learn True Health. I'm glad you're here. Have yourself a fantastic rest of your day. And enjoy today's interview.

[00:05:37] Ashley James:  Welcome to the Learn True Health podcast. I'm your host, Ashley James. This is episode 478. I am so excited for today's guest. This topic is going to be so cool. I love geeking out with the science. Dr. Nathan Bryan, I know I just got introduced to you recently and I'm surprised I haven't heard of you sooner because we can navigate the same circles. I've had Chef AJ on the show a few times, and I absolutely love her. She introduced you to me. And man, I'm thrilled to just dive into what you're doing, especially this idea that we can heal the endothelial lining of our cardiovascular system and lower blood pressure naturally. 

My husband had to be at one point in his life. He had to be on blood pressure meds. It was considered that we go to a naturopathic physician and do all this healthy stuff. It was kind of a shock. He had chronic blood pressure problems his whole life and we finally addressed it and his doctor listened. You've tried all this other stuff and let's get you on meds. And that's only lowered at about eight points. Like it wasn't anything substantial yet. All these side effects happen, lowering your life expectancy the more meds you're on. So, I don't know if that's exactly direct causation. I know that medication makes the body have to burn through its nutrient store faster. So it burdens the body to have to metabolize drugs. So, there's this give and take. Here we have a population; 1/3 of the population is obese, pre-diabetic, or diabetic. 

Heart disease is one of the top killers, along with cancer. And, of course, the statistics now cancer is on the rise. And so we have the roulette of what you want to suffer from the last 20 years of your life. Diabetes, cancer, heart disease, but that's if we go with the flow. If we eat the standard American diet, we watch mainstream media and do what everyone else is doing. So we follow Hollywood basically and follow the mainstream media diet and agenda. So we do what everyone else is doing. Go to the doctor, just let her prescriptions at you. And if you just go with the flow, you're guaranteed to be a statistic. So now you're going against the green and figured out a way to help people lower blood pressure naturally. So to heal their heart and prevent disease in a really exciting way. I'm just bubbling. I'm so excited. Welcome to the show. I can't wait for our listeners to learn how we can take control of our health with the latest science that you're involved in. So welcome.

[00:08:37] Dr. Nathan Bryan: Thank you Ashley. It's a pleasure to be with you. 

[00:08:39] Ashley James: Absolutely. Well let's start by hearing about you, your story and what led you to decipher this information.

[00:08:47] Dr. Nathan Bryan: Well, it's like a journey, right? So I think the longer I lived, the clearer the more I realized how little influence I had. I think God puts people in our lives at certain points and forces us to pivot. We have some of the grand plans when we're early starting in our careers. So it's not where we end up. I live up with no regrets and everything that's happened, the good and the bad, that got us to where we are today. But I grew up in small-town Texas and went to the University of Texas at Austin, where I got a degree in ministry. I had an opportunity to do undergraduate research there and I fell in love with discovery. I mean that was a time in the early 90s when we were overexpressing protein and bacteria. And then isolating those proteins, then being able to do structure-function analysis. So I try to figure out how does an intact protein work and what goes wrong in certain diseases. 

So then, after a degree in biochemistry, I do a bachelor's degree in biochemistry in the job market, isn't that great? So I knew I had to go on and extend my education. I went to LSU School of Medicine, where I got a Ph.D. in Molecular Cellular Physiology. There I was introduced to nitric oxide. It was a little early 2000s, right after a Nobel Prize was awarded for its discovery. And so that's when I just really got entrenched in the science of nitric oxide. We knew it was important, but at that time, there were no methods to detect nitric oxide in biological systems. It was really well known about the science of what goes wrong and people that can't make it. What are the clinical symptoms of such and there certainly weren't getting knowledge or science around any create or recreate nitric oxide in the human body? So that was an exciting time. We developed methods that allowed us to detect nitric oxide in biological samples, whether blood or tissue biopsies. I found a number or published a number of papers during that time and then left there. I went to the Boston University Medical Center in Boston at the Cardiovascular Institute. I had a fellowship in cardiology and vascular biology, and again, I had some pretty profound discoveries. And I made a name for myself as a young investigator. I was recruited to join the faculty at the University of Texas Medical School in Houston by Fred Murad, who was the department chair there. He was one of the gentlemen that shared the Nobel Prize. I found a home because it was a nitric oxide-centric department at the Institute of Molecular Medicine. 

For the first couple of years, all I did was do experiments and try to enable patents. At that point, we had enough information and the methods available that I could figure out and produce nitric oxide in biological systems. So for the first two years, I did nothing but experiments and patents to the University of Texas. Those patents were soon issued after that and then the next stage of my career was to make sure that discoveries and technology saw the light of day to retire from full-time academia in 2015. 

And I've been an entrepreneur since and on the number of companies commercializing nitric oxide technology. So my objective today is to introduce nitric oxide-based product technology and every major market segment around the world, including drug therapy, where we have drugs in phase three clinical trials for COVID. With some drug applications going in for ischemic heart disease and topical drugs for diabetic ulcers. The exciting thing is that nitric oxide does so much and is so important in human disease that there's really no indication that we could not go after any type of drug therapy. So that's kind of a 20-year story in that two minutes.

[00:12:58] Ashley James: Maybe we let's back it up to the basics for someone who's never heard of the term nitric oxide. Why is it so important? What is it do? Why is it so exciting that you've been able to figure out a way to increase it in the human body? 

[00:13:14] Dr. Nathan Bryan: Well, it was discovered about 30 years ago, so it's still a new discovery in the medical sciences. But it's a signaling molecule. It tells how cells in the body communicate with one another. It is mostly recognized as vasodilation, meaning that it dilates the blood vessels throughout the body and increases oxygen and nutrient delivery. But it's a neurotransmitter in the central nervous system. Our immune cells actually generate nitric oxide to prevent the virus from replicating and proliferating throughout the body. It shuts down bacterial respiration. So it's part of our host defense. Understanding that and all that nitric oxide does, it becomes obvious that if you lose the ability to produce nitric oxide, which occurs as we age and are really dependent upon like diet and lifestyle. A lot of bad things happen you lose the regulation of blood flow. You can no longer dilate blood vessels, so you develop sexual dysfunction. You develop vascular dementia develop high blood pressure, which two out of three Americans have an unsafe elevation and blood pressure. You develop them. You become immunocompromised. So if you're exposed to a virus-like Coronavirus, or like the flu, you get sick from it and develop the neurological disease. 

I thought the science was very clear at the time that the older you get, the less nitric oxide you make. That is what's responsible for the age-related disease, including cardiovascular disease, the number one killer of men and women worldwide. So that's what science has told us over the past 20 years. That's the missing part– the science is clear, but how do you fix it? And that's been my contribution to the field because we figured out how to develop a shelf-stable, solid form with nitric oxide. And perhaps I'll take a step back because maybe your listeners don't realize that nitric oxide is a gas. So it is produced in the lining of the blood vessels. When this gas was produced, it was gone in less than a second. To be able to develop drug therapy or any type of product technology shelf-stable that recapitulates nitric oxide signaling in the human body has been very, very challenging. In fact, big pharmaceutical companies have tried to do this for the past 30 years. They've been largely unsuccessful. But through our research program and kind of thinking differently, thinking outside the box, we figured this out and they'll have. So I think over two dozen issued patents claim to fame as we know how to make nitric oxide that's extremely valuable and profound in the way that I think people are going to be healed over the next 40-50 years.

[00:16:00] Ashley James: The first time I heard about nitric oxide was when I interviewed Dr. Cadwell Esselstyn and I'm sure you know of his work. He's also a friend of Chef AJ. He came on the show and explained that he takes people who are basically at death's door. Their doctors have given up on them. They have multiple clogs in their heart. They're even too sick for bypass surgery. The doctors say just go home and die. Unfortunately, when people usually find Cadwell Esselstyn and his book, How to Reverse and Prevent Heart Disease and he gets them on a whole food plant-based diet with no salt, sugar, and oil. Incredibly strict. He lately added a factor, which every few hours, like every four hours, he has the meat of a bowl of steamed greens, just any kind of leafy greens, like 12 of them. Pick a leafy green, steam it and then cover it in as much balsamic as you want. Any kind of balsamic. There are all kinds of flavors out there. And he says that balsamic vinegar and greens increase if, especially balsamic vinegar, it increases nitric oxide and helps heal the endothelial lining of the cardiovascular system. And I thought that was fascinating. 

And then I heard it again when I watched the movie, The Game Changers, where they follow these athletes like the Olympic athletes who have gotten plant-based. And there's this one woman who was 29 or 30 years old. She beat people almost half her age and won the gold in cycling at an almost age of 30 which is like an 80-year-old beating a 40-year-old in a marathon, right? So she said that her biggest thing was beats– because before and after exercise would increase the nitric oxide and help with lactic acid clearance. She found her recovery to be faster and she had her endurance higher up just by eating whole food plant-based, avoiding salt, sugar, and oil, and making sure she's getting enough beats and enough greens in her diet. 

So I hear that there are certain nutrients the body loves in order to make nitric oxide. You said that as we age, we make less. Is it because we're age and we're older like our telomeres are shorter or is it because as we age, we beat up our body so much, it's like failing us and we're not eating healthy, right? Eating enough nutrients like what is it about aging that has us make it less? And is it really about age? Or is it about lifestyle and diet?

[00:18:53] Dr. Nathan Bryan: Well, those are very good questions. And yes, I'm friends with Dr. Esselstyn and he made an enormous contribution to medicine. His observations are what led them through that being able to reverse heart disease. And it was our science that basically provided a mechanism for his observation. So to understand this age-related loss of nitric oxide production, there are two ways the body makes mycotoxin. The first one to be discovered was an enzyme called nitric oxide synthase. And that's the enzyme that's found in our endothelial cells. Like every second upon me, that's what produces nitric oxide when you need to increase blood flow. For instance, if you're trying to remember where you parked your car. Part of the memory recall is you got to increase blood flow to the prefrontal cortex to recall memory. If you can't dilate the blood vessels to get improved blood flow and perfusion to that area, you develop cognitive disorders and become forgetful. Same thing if you want to perform sexually, you get to dilate those blood vessels to get engorged, and you get increased blood flow. You can't make nitric oxide and you can't. 

So that's the pathway. This becomes more compromised the older we get. The biochemistry in the enzymology is well understood that it's basically due to oxidation of a molecule called tetrahydrobiopterin or BH4 that leads to enzyme uncoupling and endothelial dysfunction. So that is what we lose with age. The other pathway that Dr. Esselstyn exploits is that you can use a diet thru green leafy vegetables, and then there's a molecule called nitrate. It's inorganic nitrate. It's found primarily in dark green leafy vegetables. So when you consume those, about 90 minutes after you consume, let's say spinach or beets or kale or any green leafy vegetable that is concentrated, that nitrate is taken up in our guts and put it in our salivary glands. 

This has been known since the late 70s. And then each time we salivate now for the next five or six hours, our secreting nitrate in our saliva, in our oral cavity. And then, under normal conditions, we have nitrate-reducing bacteria that live on the crypts of the tongue in our mouth. Then these bacteria reduce the nitrate to nitrite and nitric oxide. This happens for the next six or eight hours. When we swallow our own saliva, it's enriched in nitrite. The nitrite becomes nitric oxide as long as there's stomach acid being produced. So Dr. Esselstyn is very correct in the fact that if you eat green leafy vegetables and put balsamic vinegar, which is basically acetic acid. So you're acidifying the lumen of the stomach to allow that nitric oxide being produced when it's broken down by the bacteria and then digested in your stomach. So mechanistically, that's how it's designed to work. 

The problem is that if you're using mouthwash to kill the bacteria in your mouth because of bad breath or just because of habit, then you disrupt this pathway. Or, if you're using antacid to prevent stomach acid production, you shut down nitric oxide production. And this was really the epiphany when I first had a conversation with Dr. Esselstyn. Like with any clinician, you have patients who get better and you use the same protocol on another patient and don't get better.

So why is it that one patient responds beautifully and the other patient doesn't respond at all? The explanation for that is because Nathan goes and never asks my patients if they're using mouthwash. I've never asked my patients that I put on a plant-based diet if they're using acids because clearly, if they are on that plant-based diet, it's not going to work for them because there's no nitric oxide being produced by that plant-based diet. So that was the epiphany to him and I think to a lot of people, it's because it's the microbiome, right? A lot of people are focused on the microbiome of the gut and how important that is. There are very few people besides us who ever focused on the oral microbiome or if there's dysbiosis in the gut. So you get symptoms and human disease if dysbiosis in the mouth becomes nitric oxide deficient. And there's clear evidence now. We've published on a number of others that people who use mouthwash have a higher blood pressure than those who don't. 

We've also published on the fact that if we take normal tensive healthy people and the only thing we do is we don't change their diet, don't change any other aspects of them. We just give them a mouthwash twice a day for seven days. In some patients, we see as much as a 26-millimeter increase in their blood pressure in one week. And that's the effects on blood pressure. There's also evidence now that if people use mouthwash and exercise, he loses the cardioprotective benefits of exercise. I mean, that is earth-shattering because for the most part, people try to do the right thing with good intentions. They exercise, they eat a plant-based diet, their dentist has told them at some point in life, that they should use mouthwash to keep gum disease and gingivitis away. So they use mouthwash. But yet, when they do that, they eliminate the benefits of their diets. They eliminate the benefits of exercise, and they're basically putting themselves at risk for the advanced progression of cardiovascular disease. 

So 200 million Americans use mouthwash every day and 200 million Americans have an unsafe elevation of blood pressure. That's not a coincidence. There's a clear causal relationship between the oral bacterium and steady-state blood pressure. So if you're using mouthwash, you have to stop.

[00:24:54] Ashley James: I want to back up and unpack that because I'm in shock and my listeners are too. So you said if you don't have the microbiome in your mouth and you exercise, you're losing the cardiovascular protection of nitric oxide. I'm a little confused, though. I thought you said that it was also produced in the endothelial lining. So, if you don't have the bacteria in your mouth, does that mean your endothelial lining of the cardiovascular system doesn't produce it or do you get less because the bacteria also produce it?

[00:25:33] Dr. Nathan Bryan: We thought early on, probably 15 years ago, these were two mutually exclusive events. So they were completely separated so one could compensate for the other. So that's why young kids can get away with not eating a lot of vegetables or could die because they have good in the single function. And that endothelial functions are the nitric oxide is produced. The blood vessel lining can compensate and overcome a lack of a good die. But the older you get, we know that we get the less functional. Our endothelial becomes the less nitric oxide we make. So we have to compensate for that through the diet. But this evidence points to the fact that the benefits of exercise are improvement and endothelial function. But the issue is if you're in moderately good shape and you begin to exercise, that creates some shear stress in that skeletal muscle, whether it's in the legs if you're running or biking or if it's in the biceps if you're doing curls. So the muscle tells, I need more oxygen and nutrients being delivered because you're working me harder. So the only way to do that, especially in the heart, is to dilate the blood vessels production of nitric oxide. 

So if your body can make sufficient nitric oxide, it does. And then there's an adaptive response where it actually improves the ability. So if you're stressing your body and your body goes, I need to up my game because I need to be ready for the next stressful event. There's an improvement in nitric oxide. The problem is when you have endothelial dysfunction, like older patients who have chest pain or shortness of breath. They go to a cardiologist, put them on a treadmill, and come up with some leads on EKG. As they increase the workload, and if the coronary arteries can't produce nitric oxide to dilate the coronary arteries, then that heart becomes hypoxic because it can increase the oxygen delivery to meet the increased metabolic demand. So there are changes in electrical activity. So they failed an exercise stress test. 

So your ability to produce nitric oxide predicts how well you can perform. So there's a clear association between, if you're using mouthwash, there's an association with endothelial dysfunction. So you're losing the protective benefits of exercise. There's a bit of an explanation for that because when you produce nitric oxide, it's oxidized almost immediately to nitrite and nitrate. Then your body's kind of the biomarkers we look at or plasma levels of nitrite and nitrate. So when you're exercising and that's where things like beetroot extract or titrating up your nitric oxide levels prior to sports performance because it is when oxygen is needed to make nitric oxide and the lining in the blood vessels. 

So when you reach that anaerobic threshold and oxygen becomes limiting, your nitric oxide production stops from the enzyme that makes nitric oxide. If you've created a pool of nitrites because you've generated a lot of nitric oxides prior to the anaerobic threshold. The nitrite under those low oxygen conditions actually generates nitric oxide in an enzyme-independent manner.

[00:28:57] Ashley James: Does your body take the nitrite and then in an anaerobic state, turning into nitric oxide?

[00:29:07] Dr. Nathan Bryan: That's right. So what happens? The pKa of nitrites is about 3.4. So they're mammalian enzymes that, specifically as the pH of the muscle decreases or the tissue decreases, that nitride becomes nitric oxide. So then, what does that nitric oxide do? It does a lot of things. Number one, it binds to cytochrome c oxidase and mitochondria so that you get oxygen diffusing further into tissue. And you push that anaerobic threshold back, so you get less lactic acid buildup. You can oxygenate that tissue to where you can turn the nitric oxide back on. It's a self-feeding or feed-forward mechanism that's all dependent upon your steady-state levels of nitrite. And your ability to titrate up these nitrite stores prior to reaching that anaerobic threshold.


[00:29:54] Ashley James: Now, we don't need to get smoked bacon with potassium nitrite in it to get our nitrites. It's a different kind of nitrite and nitrate. I've always thought if people knew what they put in deli meat to preserve the meat, so the meat didn't look gray. How it affects the kidneys and how it affects the circulation in the body that they would not eat that. Those preservatives in that state are not what you're talking about. Can you explain how do we help the body? Where are we getting the nitrites and nitrates from our food? Is it more leafy greens and the beet? Is that the best thing to do to get it from our food as the best source?


[00:30:50] Dr. Nathan Bryan: Well, yes. So it's been a misconception and this may not be surprising to you but the media and big Pharma have not always told the truth. In terms of what's good for us and what's bad for us. So the nitrites and nitrates found in green leafy vegetables are the exact same molecule they used to cure hotdogs. So there are a lot of other preservatives in those curing processed meats that probably aren't good for you. But nitrate and nitrite are protected. 

If you think about the science of curing, what are they doing? Well, you're preventing lipid oxidation, but that's pretty important in human physiology. So nitrite has that. So that they end up in processed meat, it prevents listeria clostridium along with these foodborne pathogens. Well, that's pretty important in human physiology as you can prevent bacterial outbreaks, and then it binds to the iron of myoglobin, turning into a nice pink color. It does the same thing to hemoglobin. It binds to hemoglobin and allows oxygen to be delivered throughout the body. So the same chemistry involved in meat curing is the same chemistry that we're utilizing in human physiology to prevent oxidative stress, prevent inflammation, and improve oxygen delivery to a working muscle. 

So here's where the misconception came and I don't deny the data on the fact that there's an increased relative risk on people who eat curing processed meats and have a slight increase in the risk of certain gastrointestinal cancers. That's called an association, but it's certainly not causation. In order for you to establish causation, you have to have a biologically plausible mechanism that explains that observation. So in the 1960s and early 70s, they go– oh, well, it has to be nitrite and nitrate in the curing processed meats because of those form nitrosamine and nitrosamine cause cancer. So there's their biologically plausible mechanism. 

That stood for about 40 years until the discovery of nitric oxide. Then it was realized, well, nitrite and nitrate are actually produced and obviously, why would our bodies naturally produce carcinogens? And then, the national government, the National Institute of Health and Public Health and Human safety, did long-term safety studies on nitrite and nitrate in our food supply. What they found was the National Toxicology Program, that's the Gold Standard in Toxicology. So they did those escalations for both nitrite and nitrate in male and female mice, rats, and rabbits. Do you know what they found? They prevented cancer. They didn't cause cancer. Actually, in many cases they prevented cancer. 

So that story began to fall apart, and then if that were true because 85% of the nitrate and nitrite exposure we get from our diet is from green leafy vegetables. Only 5% comes from cured and processed meats. The other 10% comes from swallowing their own saliva. It's 10% because the nitric oxide produced endogenously is oxidized to nitrate. That nitrate in the body doesn't discriminate the nitrate that comes from spinach versus on which is formed from enzymatic NO production. So then our body puts the nitrate in our salivary glands, we salivate, generate nitrite, swallow the nitrite, and become nitric oxide gas. So if that were the case, vegetarians or people who had a plant-based diet would have about a 10 times higher incidence of cancer and heart disease than non-vegetarians and we know it's just the opposite.

[00:34:33] Ashley James: Right. If nitrates and nitrites were the cause. So interesting, though. We want the benefits that you're talking about having plentiful amounts, adequate enough amounts with as much nitric oxide as the body needs, right? We want that and it doesn't sound like we'd get it from eating a lot of cured meats. You might get like you said, 5% and you're not getting all the benefits on all the other nutrients that come from eating plants. So there's a significant percentage when you eat plants versus the cured meats, but also really important. Its 10% is from your oral health and having a healthy microbiome in your mouth, and not using mouthwash. It makes me think about people who are on antibiotics, and if that's wipe-out those good bacteria, they immediately wipe out 10% of their nitric oxide production.

I know you'd blow my mind in this interview, and we're just warming up. I only knew about vasodilation and that's why I was excited. I knew that people reported that it helps with endurance and recovery. So it helped lower lactic acid buildup and vasodilation which is so important. Can you talk a bit more about the signaling of it? These new discoveries about how nitric oxide is used to help the parts of the body signal and talk to each other.

[00:36:10] Dr. Nathan Bryan: Well, one of the most profound discoveries and realizations in nitric oxide signaling was in 2015 with Jonathan Stamler, a good friend and colleague in Case Western, who published a paper that revealed that nitric oxide is required for oxygen delivery. As part of its signaling, nitric oxide can bind the metals or activate second messenger systems. But it can also bind to tiles on proteins. These are the sulfur-containing amino acids on proteins. So in oxygen delivery, when you breathe, you pick up oxygen and exhale CO2. And when the red blood cells go from the arterial side to the venous side through the capillaries, they release oxygen. That's where oxygen and CO2 exchange occurred in a small red blood vessel. In order for oxygen to come off hemoglobin, nitric oxide has to be bound. If we don't have nitric oxide bound to hemoglobin, it doesn't undergo that structural change, which is called the Bohr Effect, and oxygen doesn't come off. This became obvious over the last two years in COVID because the problem with COVID is a loss of blood oxygen saturation. So they become hypoxemic and put them on oxygen. If they don't improve their oxygen saturation, they put on a ventilator and 90% of people put on a ventilator and die. That's the root cause of COVID. 

In 2020, we got an investigational new drug application approved by the FDA, where we started our nitric oxide drug and phase three clinical trials for COVID. We see the importance of nitric oxide and oxygen uptake and oxygen delivery. In our drug study, we're seeing COVID patients that get sick and they get blood oxygen saturation in their below 80, sometimes in their high 70s. Typically, that patient would be put on vent immediately. But they take our nitric oxide drug, and within eight minutes, we see blood oxygen saturation goes to the high 90s. 

And that explains everything we know about COVID over the past two years and that 15 years was the first SARS COV-1. The people who get sick and hospitalized from COVID are the ones that can make nitric oxide. Who are those? Those are the elderly African Americans, people with underlying cardiovascular disease, high blood pressure, diabetes, and smokers. Is that patient population this nitric oxide deficient? And few are nitric oxide deficient and you get exposed to COVID. The virus rapidly replicates and proliferates throughout the body. You get the systemic disease, you lose oxygen saturation, and in the hospital, you are put on a bed and you die. The simple fix is simply taking our nitric oxide drug, improving signaling, preventing vascular inflammation, improving oxygenation and you kill the virus.

In 2005 papers were published showing that nitric oxide prevents Coronavirus replication. So that's probably one of the most important aspects of signaling. In the other aspects of signaling, you said earlier that loss of nitric oxide production causes telomere shortening. The signaling aspect is that you need nitric oxide to transcribe and make the telomeres enzyme, preventing telomere shortening. It co-localizes with nitric oxide synthase. If you can't make nitric oxide, you don't get to the polymerase, and you get telomere shortening. The other important component may be the most important is stem cell function. Nitric oxide is what tells our own body and tells our own stem cells in need to mobilize and differentiate. If you have a cough or an injury, nitric oxide is the signal that says, hey, I'm getting an injury. We need to mobilize our immune system and increase blood flow to that side of injury. And we need to make new cardiac myocytes, for example, or we need to make new neurons because we had a stroke. And if you can't make nitric oxide in the body, it doesn't get the signal to go there and repair any damaged tissue. The result is you don't recover from injury. If you have a heart attack or stroke, typically, you lose neurological function. You lose cardiac function unless you do stem cells or stimulate your body's own stem cells. And you can only do that through improving nitric oxide.

[00:40:48] Ashley James: I see that application for your drug for the emergency room. Someone comes in with a stroke, they just had one, and it would make sense to give it to them. Someone just comes in having a heart attack, and it makes sense to give it to them. You want to do everything you can to increase oxygen to oxygen-starved tissues because of a stroke or a heart attack. But, of course, my goal in this podcast is to help people prevent illness in the first place and help people reverse illness wherever they are. Whether they're in early stage or even late stage. As long as your heart's beating and you're breathing and you're able to take action for yourself, then there's hope. And there are things you can do to help your body heal itself. But even if someone were to go to the emergency room, this was available to them. And they didn't know about natural medicine and then they got sick. So that would be a fantastic emergency medicine at that moment to help them have a better outcome. So I'm really excited about your drug. 

As a society, we overuse drugs, but drugs aren't all inherently bad. There are some amazing lifesaving drugs and the problem is that if you only go to the doctor, they throw drugs at you and don't help you change your lifestyle and diet. And doesn't look into the latest science of things. Then there were just throwing a bunch of drugs at a problem that might have been a diet or nutrient deficiency or diet problem or a lifestyle problem. So it's really good, my listeners know. Does anybody have new listeners that haven't thought of it this way? You don't take your broken-down car to a plumber. I mean, that's not plumbers, it's a mechanic, right? So you take your car to a mechanic. Don't take your health, always to the same doctor who only has a limited world view on health right?

I remember I'm from Canada. I remember I'm coming to the states and I picked out that I thought it was a good doctor. He was an osteopath, so I thought it was more holistic-minded. This is back, and we lived in Vegas, I lived in Henderson. So I went to an osteopath, really great guy. He was referred to me by my chiropractor's wife, who's a functional medicine practitioner and she thought that this would be good. I go to him and I'm complaining about this pain in my ovary and I don't know if I'm having a cyst or what's going on. I just want an ultrasound. I just want to make sure everything's okay. I'm kind of nervous about it. And he walks into the office holding his prescription pad, writing a prescription for pain, and he's walking in. I'm like– I don't want pain medicine. I'm in pain, but that's okay because pain is like notifying me that there's something wrong and as a Canadian, it's harder to get pain medicines that I don't know. 

It's different now, this is back in 2008, but it's harder to get paid for medicines in Canada. But in the States, all I had to do was say I'm in pain and they're like– oh, how many pain prescriptions do you want? I remember I went to a doctor, doesn't stick to the sore throat. It's just a sore throat, but it's not going away. I just want to get it checked out. I'm feeling a little nervous about it. And this was before I was into Holistic Health. She wrote me a prescription for some cough syrup that had a bunch of pain meds in it. I thought this was crazy. Like I've never taken a cough syrup with pain meds before. Of course, it numbs my throat and everything. But it's just this idea that we're over-drugging ourselves. 

So we don't throw the baby out with the bathwater. If there's a drug and you're developing a drug that can increase nitric oxide that can save lives at the moment, that's amazing. And then, of course, in the long term, I'd love for everyone to learn what they can do to increase nitric oxide in their lifestyle and in their diet as much as possible. But, as you've already mentioned, eating leafy green vegetables helps hugely and making sure to take care of your oral microbiome. Don't do things that kill the microbiome in your mouth. So we've got two very easy to follow and very effective tips. Are there any other lifestyle tips for ensuring the protection of our nitric oxide production and in anything else we can do to enhance nitric oxide production?

[00:45:20] Dr. Nathan Bryan: Yes, there's a lot. So let me go back because you make some very important points there. Interestingly, when I first found the patents and some medical school faculty, we had access to the hospital and patients. Actually, Jim Wilson, who's a famous cardiologist who unfortunately passed away last year, his idea was to use it for heart attack. So if you've got what's called an ischemic patient, [inaudible 00:45:47] which is ischemia, then the problem is they have an acute obstruction in a coronary artery so we could dose them in the field, bring them back and see if we can protect the heart from injury. So, it made perfect sense. But obviously, that's a high-risk patient population. People are going to die and so we just made the decision well. With this early technology, let's not put it in high-risk patients. But you hit the nail right on the head. So whether it's an ischemic stroke or heart attack, it's a very important application. But as you also said, prevention is much easier than treatment. So we have to address it before you have a heart attack.

Then going back to drugs, I'm trained as a drug discovery chemist that's designed to understand human disease to the extent that we can rationally design drugs. My philosophy is much different than major drug manufacturers because what they do is create a synthetic compound. It's typically, probably 90% of the drugs out there what's called enzyme inhibitors preventing the activity of a certain enzyme. That's called pharmacology and there are always consequences that cause side effects or body is not designed to inhibit an enzyme for the rest of our lives, which is what drug therapy does. So what we've done is called restorative physiology. We understand the enzymology of many different proteins and enzymes, primarily nitric oxide-producing enzymes. We know what goes wrong in people and we can restore the function of that enzyme.

So when the drug therapy that we develop is restorative in nature. It's not an inhibitor. It's basically giving back to the body what's missing in terms of nitric oxide. So we know how much nitric oxide a healthy human makes, and we basically deliver that and recapitulate nitric oxide-based signaling in the human body. So drugs or anything that goes through FDA-approved clinical trials, and their prescription. Although we do have a drug discovery program and biotech company through, nitric oxide innovations are different than the drugs on the market. For most people and probably many holistic people, drugs are bad words. But what we're doing is really a drug intended to give the body what it needs. The body heals itself. So that's our drug discovery platform. Trying to get these different drugs through the FDA-approved clinical trial, which by the way, is a very heavy lift, especially competing against people like Pfizer, Moderna, and J&J. Government employees doing their clinical trials for them. But you don't need that. 

Going back to what we can do to stimulate our own nitric oxide production or prevent the age-related decline. You do two things, you stop doing the things that disrupt nitric oxide production and start doing the things that stimulate it. So we can address both of those. So number one, if you're using mouthwash, you have to stop. The evidence is clear. I was in the Doctor Show last year where we revealed that mouthwash makes the blood pressure goes up. With mouthwash, you lose the benefits of exercise. So if you're using mouthwash, you have to stop. Don't overtake antibiotics. Over 200 million prescriptions are written every year for antibiotics. If you get an active infection, the antibiotics are very important but don't overdo it because you're killing the bad guys, but you're also killing the good guys. 

The other thing is fluoride toothpaste or fluoride rinses, Fluoride to antiseptic. It's a neurotoxin, and it kills your thyroid function. So if you're using fluoride toothpaste, throw that away. Never buy fluoride toothpaste again. There's a reason we have an epidemic of hypothyroidism. Fluoride competes with iodine binding to thyroid hormone can't convert T4 to T3 with Iodine. Then the other thing is antacids. In over 200 million prescriptions are written for antacid every year and that's not even counting the number of over-the-counter purchases. You have to have stomach acid and as Dr. Esselstyn says, take some apple cider vinegar before each meal. Acidify the stomach to get a better breakdown of proteins. You get your nitric oxide being produced. So those are the three things that will really make a huge difference in people's health. Throw out the Fluoride, stop using mouthwash, and stop using an antacid. So those are the three things you must do to get out of your body's waste that can make nitric oxide. And then do the things that stimulate more green leafy vegetables, moderate physical exercise, and 20 to 30 minutes of sunlight a day. For those that live in the North and there are long winters, you have to get an infrared sauna or infrared light.

[00:50:30] Ashley James: I have Sunlighten Sauna and it's the coolest thing ever. It's near, mid, and far-infrared. I feel like a new person. I love using it. I live out in the Pacific Northwest and it's 4:30. The sun goes down at night and doesn't come back until 7:30. So we got those long winters, but I feel like a new person since I got that Sunlighten Sauna and I absolutely love it. I interviewed the founder of Sunlighten and it was a great interview. She started the company because her brother was dying of cancer and doing everything he could to fight it. Maybe it was cancer because it was a few years ago when we did the interview. I'm pretty sure it's cancer but he was very sick. I can't remember what it was. It might have been cancer or might have been Lyme Disease but he was basically laid out flat on the couch. He was super sick. And then he found out that infrared could help him and it gave him a leg up. Then she developed that company and it's all non-toxic.

My listeners get a great discount when they check out Sunlighten Sauna. I absolutely love Sunlighten Sauna technology. Now, I know another reason why I love it. It increases nitric oxide production and helps my body to do that. So you talk about Fluoride, my question is, what about Fluoride and Chlorine in that drinking water? We should do our best to drink water that doesn't have Fluoride in it and Chlorine. Does Chlorine also affect nitric oxide and does it not also disrupt the microbiome?


[00:52:06] Dr. Nathan Bryan: Chlorine and Fluoride. If you go back to the periodic table, these are a group of elements called halogens. There's Fluoride, Chlorine, Iodine, and Bromine– I don't have in front of me, but those are the major ones. The biggest thing with Fluoride, Chlorine, and chloride is they compete with Iodine, binding the thyroid hormone. So most Americans are deficient in Iodine, 95% of Americans because the only dietary sources of Iodine are typically seaweed or iodized salt. So we don't get enough Iodine in the body, yet we're exposed to Fluoride in our drinking water. Fluoride in toothpaste. Most humans have more Fluoride and chloride in their blood-streaming cells than Iodine. They're the same type of chemistry with the same halogen properties on that one row on the periodic table. They have similar functions and similar chemistry. So they act as competitors in binding Iodine to thyroid hormone. So, you become hypothyroid. I tell people that everybody has to supplement with Iodine. Everybody's deficient in Iodine. 

Going back to your question, the municipal waters are probably the worst thing in the world you can drink. Not only does it have Fluoride and Chlorine, but it has drug metabolites in it. So you have to have a pump filtration system to remove all these toxins from the water supply. People think it's bad to drink it. What's worse, it's bad to cook in it. So it's even worse to bathe in it because you're heating the bathwater up to sometimes 104, 110 degrees, then you volatilize and there are chloramines and you inhale it. So you get better absorption, transdermal through inhaling it. Volatilize by heating the water and people get sick and get a chronic illness. So you have to eat, drink and bathe in good clean water and not municipal water coming out of the pipes of major metropolitan areas.


[00:54:12] Ashley James: I absolutely agree with you. I felt amazing when I lived in a place with the well water. It makes such a difference to bathe in water, drink water, and cook with water that is from the ground that doesn't have any fluoride, Chlorine, or any chemicals in it. Oh, so good. I recently found a water filter that's affordable, that removes everything. It's called Zero water. I've been meeting to contact the company and see if they could get whether science guys to come on and explain how it works. But it's better than any other filter I found and it's like 30 bucks, and it looks like any other kind of picture. They have the bigger ones, like a 23 cup one, and that's the one I got. But it comes with a tester that tests the total dissolved solids of parts per million. And sure, it sets to zero and they give you the little machine that tests the water for you. 

So that you know when it starts showing numbers on it and when to replace the filter. It takes for me about every two months to replace the filter. I'm sure up it works as well as a four hundred dollars in reverse osmosis and it's only like 30 bucks. So lately, I found out a few months ago and the water tastes so good coming out. Now that we're living in a place with municipal water, I need to find something better, even better than my Berkey. My Berkey wasn't removing everything. But it [inaudible 55:45] everything. So I thought that was really cool. You've given us so much information and I keep thinking. You've created some products that we can use because I'm going to do everything you said. And in addition to that, I want to take it to the next level. I'm sure my listeners are the same, or they're like—well, what else I can do. 

You've given us the life hacks and things that we can make sure that we're doing, which are simple enough. Clean water, clean toothpaste, no mouthwash, take care of the microbiome, eat foods like nice leafy greens, and eat food that increases nitric oxide. But in addition to that, what else can we do to take it to the next level and get the maximum benefit considering that nitric oxide does so much more than I thought that it helps. If it's helping with telomeres, it's helping extend life. It's helping literally tell your DNA to live longer. I heard you mentioned how it helps mitochondrial function. I don't quite understand exactly what you said and how it affects viral or suppresses viral production in bacterial production. I understood that it is fundamental to the immune system that your immune cells help make it and the signaling within the cells. Vasodilation like there are so many aspects. One point alone, it increases oxygen, drives deeper into the tissue and pushes back lactic acid. When I go to exercise, I hate it when I'm getting started and my muscles are already fatigued, burning and I'm already anaerobic. 

I look at my son, who's about to be seven. I remember having energy for days. I can take this kid to play areas and I'm waiting for him; my butt gets numb, or my feet get cold. Something like my body is hanging out and chilling with other moms. I'm waiting for my kid to get tired—three and a half hours into a play area. I'm bored and cold and ready to go home and he's just like—go, go, go. To have that fitness level again, anything to increase that ability to go longer and feel like you're seven again. 

So tell us about the products you've created and offer a fantastic discount to the listeners. We are so grateful for giving us 10% off. Every little bit helps these days. The coupon code, of course, we're all everything when we get a discount. We always ask for the coupon code LTH, which is Learn True Health podcast. So LTH is a discount. You have several websites, but the best website for all our listeners to go to and the easiest one is n as in the letter n, one, o, one dot com. It's n1o1.com. I'm sure there's a reason for that. Is that the nitric oxide molecule?

[00:59:17] Dr. Nathan Bryan: That's one Nitrogen and one Oxygen. 

[00:59:20] Ashley James: Yes, like H2O is water. So it's n1o1.com, and that one does not spell out n1o1.com. But, of course, the links to everything that we're talking about today was going to be in the show in today's podcast in learntruehealth.com. But when we went to n1o1.com, I was surprised about the products because the first thing I saw was some face creams. And I'm all about looking good. But here you are, scientists, about how to increase nitric oxide production. So let's start with the obvious, what's up with the face creams?

[00:59:55] Dr. Nathan Bryan: This has been an evolution. I've been doing this for 20 years and as I mentioned early on, when we started going and when we solved the riddle on how to create nitric oxide in a safe and effective manner, it changes everything. So when we started developing product technology, we first launched in the dietary supplement space, and we set good results there. And then I get to think, what else that is people forget the skins and organs. Like the heart, if you have an interruption of blood supply to the heart, what happens? The heart fails. If you have a disruption in the blood supply to the brain, well, the brain fails. Just like any other organ, if you have decreased blood flow to the skin, what happens? It fails. What does the failing skin look like? When you lose collagen and you lose hydration, fine lines and wrinkles start to appear and the skin hangs and drupes, you get dermatitis, and you get age spots, and that's aging. 

What is the root cause of aging? Well, it's a lack of nitric oxide production. So we figured out how to deliver a solid dose form of nitric oxide in the form of a lozenge. So we created a door chamber serum that when you mix these two components together, you basically take one pump from one side, one pump from the other. So you mix it together, then chemistry starts as normally would on the skin's surface and we generate nitric oxide gas. This is the coolest show in the history of any product technology. Aesthetics and skincare's multibillion-dollar. People buy a lot of stuff and most cosmetic skincare products are masking. They hide the blemishes, and they hide the fine lines and wrinkles. They don't get to the root cause. 

When you apply this to the skin, you'll see it turned pink. What is that? That's the infusion of blood and oxygen to that area. The nitric oxide is the gas part that diffuses above the skin, but part of it diffuses into the dermis and opens up capillaries. It gives blood oxygen which is blood, into the cells, just like everything we've discussed. What does that mean when you get oxygen nutrient deliveries? Stem cells begin to turn on, so you get to regenerative cells, so they slough off the old cells. We regenerate new cells, and we do biopsies. We've seen improvement in collagen deposition, cellular hydration, infections, whether it's some dermatitis or acne. We kill the bacteria, fine lines and wrinkles disappear, and so just like we can recover. 

Our nitric oxide can make a heart attack, but there's injury and reduced blood supply to the heart. We can overcome the effects of loss of fusion to the skin by providing a source of mycotoxins in the body. Otherwise, it didn't make it. The result is that we've got four published clinical trials on that and see improvements from fine lines and wrinkles to scar remediation, acne, eczema, and any type of dermatitis. Again, it doesn't mask. We're getting to the root cause of that underlying skin disorder or just preventing the looks of aging. So that was the N101 serum and then we created an entire line. We had a glycolic wash that helps remove the old cells because we're improving cellular turnover like a colic wash that gets rid of the old cells so that the new cells can come forward. We got an eye cream and a face cream that contains peptides and growth factors. It's a really remarkable system and as they said, you don't have to guess if this product is working. You can see it working right between your eyes. We call it the pink glow, the Pneuma glow.

[01:03:46] Ashley James: So it's helping increase oxygen to the cells that aren't getting enough oxygen, which is then all the cells are just functioning better. It sounds like the fountain of youth. It sounds like it's going to pour the fountain of youth on my face. I'm really excited about that. Luckily, I don't have any major skin issues. But I hit my 40s now and I want to prevent looking like a leather boot in 10 years. I'm excited about that. I have a little bit of rosacea that my grandmother and my mom had. I'm not going to blame my genes. I'm sure that there's something I can do to change. I've always been figuring out things in my diet and my lifestyle to improve. But it would be neat if it helped with that. Does it help reduce acne because the bacteria are anaerobic bacteria? The bacteria that causes acne, is it basically killed because the tissues are oxygen?

[01:04:54] Dr. Nathan Bryan:  It does two things. There's clear evidence of a mechanism of how nitric oxide kills bacteria. It binds to the iron-sulfur centers, which are the respiratory sites of bacteria. So basically, it suffocates the bacteria. So there are clear antimicrobial, antibacterial effects of nitric oxide. So in acne, it's doing two things. It kills the bacteria's active infection in the pustules but also calms the inflammation and mobile and gets the blood supply there. So you shut down the immune response because the immune system doesn't need to be activated. There are no bacteria and then you suppress the inflammatory response. That's how you get rid of acne.

[01:05:35] Ashley James: I apologize if you said this before. I just really want to be clear about it. Does nitric oxide in every tissue of the body decrease inflammatory response?

[01:05:53] Dr. Nathan Bryan: Yes. I mean, that's part of nitric oxide drops. In acute inflammation, whether it's an injury, whether it's a cut or whether it's an exposure to an infection. An acute inflammatory response is necessary for our survival and part of that is mediated through nitric oxide. So you have to mobilize your immune system, dilate the blood vessels, and then go and isolate that source of infection or injury to the immune cells. So it generates a lot of nitric oxide at the site of injury. And that happens for four or five hours and then the inflammatory immune cascade goes away. 

The problem with chronic inflammation, there's no off switch. So what nitric oxide does, when you have whether it's acute inflammation in the gut, whether it's ulcerative colitis or inflammatory bowel disease or rheumatoid arthritis or lupus or any autoimmune disease with chronic inflammation, it shuts down systemic nitric oxide production. So nitric oxide, one of its roles is to shut down the inflammatory response and inflammation. The earliest stages of that are what's called microvascular inflammation. 

When you get monocytes and neutrophils that stick to the lining of the blood vessel, they migrate through. They elicit an immune response. And that's the inflammation, oxidative stress and immune dysfunction that occur in every inflammatory condition. If you restore nitric oxide production, primarily endothelial nitric oxide production, you prevent that entire inflammatory cascade. You suppress inflammation. You suppress the immune dysfunction or shut down the oxidative stress associated with all of it. One of my patents is on a method of reducing inflammation as measured by C-reactive protein. So when we improve nitric oxide production in the human body, we decrease C-reactive protein, which is an acute-phase marker of inflammation.

[01:07:50] Ashley James: That is so cool because so many doctors say inflammation is the root cause of the problem and it's like– no, you're going to go deeper.

[01:08:03] Dr. Nathan Bryan: Inflammation is the consequence of loss of nitric oxide.

[01:08:05] Ashley James:  Right. I've interviewed several doctors that say too much lactic acid is the cause of all diseases. It's like they all have a piece of an elephant. Have you heard that? I don't know if it's a parable. You've heard the story of 12 Blind Men is all touching a part of an elephant. And they're all arguing like– no, describe the elephant. Well, it feels large and leathery. No, it feels like a rope. No, it feels like a very thin thing. No, it feels round like a hose. So each person is touching a different part of the elephant. So we have to be careful not to treat the smoke but go after the fire. Imagine every time you show up to a fire, and we saw firemen putting it out, and we're like—aha, firemen caused the fire because every time we see a fire, there's firemen. Or oh, let's start treating the smoke. See the smoke? There's smoke. We should treat it and what's causing the fire and how to put it out. 

So inflammation is a byproduct. Lactic acid is a byproduct where we need to keep going deeper. Yes, everyone wants to address decreasing inflammation. Everyone wants to eat a low inflammatory diet. Doesn't want to do anything in your lifestyle, your diet that increases inflammation, just like you don't want to have too much lactic acid. And you want to make sure you have enough oxygen for yourself and this is all very important. But what is the root? Get to the root. We're seeing that nitric oxide is the absolute root. We have to make sure we have enough of it or else everything just becomes the standard American statistic. One in three people is dying of something right now and 70% of our population is on at least one prescription medication. I would say 70% of people in America probably have low nitric oxide, given what we're hearing today.

[01:10:10] Dr. Nathan Bryan: You made a very good point. I just want to expound because I get questions and everybody can research now. They can go to Google and put it in and find anything they're looking for. You can get the answer to whatever you're looking for, whether it's right or wrong. There's an answer out there. I read a paper that says in chronic inflammation, and nitric oxide contributes to tissue damage during that inflammation. So nitric oxide should be contraindicated inflammatory disease. If you read the literature, we looked in lupus or Parkinson's disease or ulcerative colitis in these scientific papers. In the tissue pathology reports, we found an increase in nitrotyrosine and peroxynitrite. So nitric oxide is causing that damage. So it's the exact same analogy you use.

When there's a crime, the police show up at the crime scene. The interpretation isn't that the police cause the crime. But, of course, nitric oxide is there in that inflammatory. That's its job because it's there doesn't mean that it's contributed to the crime or caused the disease. So it's there to clean up the mess. So you have to be careful on how you interpret data. And scientists are famous for this. You give the data and there's a misinterpretation of the data. Most of the data out there can sometimes be misinterpreted by the authors of the paper and even by the people who read it. 

So it's clear that low nitric oxide is bad. Too much nitric oxide is bad. Too little water is bad, too much water– obviously, if you drink too much water in a short period of time, your [inaudible 01:11:55] and you'll die. So everything in moderation. It's very important to realize that you have to figure it out and generate the right amount of nitric oxide at the right time and in the right place. That's what we've been able to figure it out over the past 20 years and nobody else has been able to figure this out.

[01:12:13] Ashley James: Okay, that brings me to the question. How much is nitric oxide too much? How do we know if we're reaching toxic levels of nitric oxide? To eat four cups of leafy greens a day, you're not going to kill yourself. If you try to eat four grocery bags a day, probably you would explode. Could we get toxic with nitric oxide through– you've got nitric oxide lozenges. I'm excited about learning about that. It is my next and I want to explore that. But we're doing okay. So we're going to do everything you've already said, eat healthily, and make sure we're not killing the bacteria in our mouths. And, of course, under natural intervention, we wouldn't have too much nitric oxide, at least. I'm guessing. Let me know if I'm wrong. In addition to that, I want to increase my nitric oxide more and I want to take your lozenges. Could I become nitric oxide toxic?

[01:13:13] Dr. Nathan Bryan: Yes, very good questions. Now, let me go back and hit on the points that you brought up earlier again. So you mentioned green leafy vegetables and eating a good clean diet. Here's the challenge. We did this and we published this in 2015. We wanted to answer that same question you asked. How much broccoli or celery would I need to eat? How much spinach do I need to eat in one serving to get enough nitrate in that food to normalize my blood pressure and improve nitric oxide production? A very important question because if we can answer that question, we can change the strict guidelines. We can get people off blood pressure medicine simply through dietary intervention. 

And we can recapitulate Dr. Esselstyn's work in patients with full-blown coronary artery disease. So in order to answer that question, we went to five different cities across the US. We went to the same retail grocery, we bought the same vegetables and brought them back to the lab and analyzed them. So what we found was pretty striking. We found that if you lived, for instance, in Dallas or Chicago, and you went to what's called [inaudible 01:14:29] or some retail grocery. So you bought six stalks of celery and you consume those six stalks within 20 minutes, which would give you enough nitric to normalize your blood pressure. 

If you lived in New York, you'd have to eat about 40 stalks of celery. So there are regional differences in the nitrate content of vegetables, and it's all across the US. So we went to New York, and we went to Raleigh, Chicago, Dallas and Los Angeles. There's as much as 50-fold difference in the nitrate content of broccoli or celery in New York, as there in Dallas or Los Angeles. It holds true for lettuce, spinach, and every vegetable we measure. So the point of that is that there's no way in hell we can make recommendations because it depends on where you live and how your vegetables are grown. By the way, those were conventionally grown vegetables. We also compared it to organically grown vegetables and found that organically grown vegetables across the board have as much as the five to 10 times less nitrate than conventionally grown. The variation is much higher, maybe a hundredfold difference in nitrate content of organically grown vegetables from different regions of the US.

So the point is, you cannot eat enough, just like you can't eat enough curing processed meats to get enough nitrite/nitrate to lower your blood pressure. You can't eat enough organic vegetables to get enough nitrate because to have an organic label, and you're not allowed to add nitrogen-based fertilizers to the soil. So as a consequence, the soil is nitrogen deficient, and the vegetables that are grown in it don't accumulate nitrate. Without nitrate or nitrogen, they don't assimilate other vitamins and minerals. So organically grown vegetables are healthy simply because they're not exposed to herbicides or pesticides. But they're depleted of most nutrients, including nitrate. 

So, that adds another level of complexity to trying to do the right thing. Yet not getting what we are designed to be and I've seen data. Since the 1940s, there's been a 90% decline in the trace minerals and nutrients in the food that's grown in the US. So we have to feed a growing planet, and that increased deficiency of food production has led to a decrease in nutrient absorption and assimilation. So we're producing a less nutritious product globally. 

[01:16:58] Ashley James: Exactly. And then we're getting all these nutrient deficiency diseases, and someone can be obese and nutrient deficient at the same time. And one of my mentors, Dr. Joel Wallach, talks about his first degree was in soil agriculture. And then, he was a veterinarian, pathologist, and research scientist and later became a naturopathic physician. So here's a fun story. You should check out his story of it. He saw early on like calf pellets of all these great vitamins and minerals. So he started eating calf pellets as a kid because he looked at the package and asked his dad– Dad, why are we giving all these minerals and vitamins? He's in his 80s, so like it was 70 years ago. So why are we giving all these nutrients? Why are we taking these nutrients? It was explained to him that– we'll if we use a human medicine which is a way to get sick and go to the doctor and take a bunch of tests and be put on drugs, right? Human medicine.

If you use human medicine for cattle, for beef farming, right? The steak would be $500 or $1,000 like a burger with beef, $50 or more. That's because it's for profit medicine. But with the poultry, pork, and beef, they need to keep the costs down while keeping the animals alive and making big animals. So what do they do? They try to prevent disease and they do that by making sure that there's enough nutrition in their feed. Yet they make sure there's enough nutrition in our food. 

So Dr. Wallach jokes about it, but he says that your chickens are being treated better than you are in terms of the amount of nutrients. In terms of the amount of nutrition there, the food industry is not interested in making sure you have 60 essentials, meaning the body needs these things to function. It's 60 minerals the body needs, and there are 77 trace minerals and elements that we thrive on. They're not in our food, and yet we're giving vitamins and minerals to animals to help prevent disease and make nice big animals so they can make a profit. So it just drives me nuts hearing about that. 

Someone in Texas eats a few stalks of celery, lowers their blood pressure and is great. But someone is listening in Wisconsin, or Seattle or New York, or in a different country altogether. No matter how many stalks they can fit in their mouth, they are not really getting the results and that's super frustrating. But that goes to say when selenium. People will say– off to sleep and don't have to be grown in selenium-rich soil just like– oh, my iron is low. I'm going to have more spinach. I love spinach. Most spinach is hydroponically grown. It only needs NPK water and sunlight to grow that can be completely void of 50 or more minerals. So there doesn't have to be minerals in your food for them to grow food anymore. Even if you look at Franken foods that are packaged foods, these foods don't have to have nutrients that your body needs. Which now we know is directly related to your nitric oxide production. 

So, what's the solution? Obviously, still eating a clean and healthy diet, try not to get pesticides and all that. I mean, growing our own food and making sure we put in blood meat or whatever it has high nitrogen in the soil as we grow our own food. That would be one solution. But what's the solution for someone who is done feeling sick and wants the benefits that you spend over 40 minutes talking about all the benefits of nitric oxide. What's the solution? If it is your lozenges that you've created. The next concern is what's the good amount to take because that person in Texas is actually eating just accidentally getting enough nitrates and nitrites to produce nitric oxide. They could take two lozenges versus someone in New York who can be taken few. How do we gauge this?

[01:21:23] Dr. Nathan Bryan: Yes. A very, very good question and very important question. And that's where the innovation comes in because we realized a long time ago that very few people do through diet, work, or lifestyle or getting enough nitric oxide. So you almost have to have product technology. You almost have to supplement with trace minerals and nutrients, which I do every day. Because we're not getting it from our food supply and I live on hundreds of acres in Texas. We grow our own food. We raise our own beef in the food we eat. So even if we're still not getting all the trace minerals we need, you have to supplement. 

There are two main causes or two main signs of toxicity for nitric oxide. There are only two. So one is methemoglobinemia which means that you take so much that you oxidize the iron and your red blood cells and you can no longer transport oxygen. So what that looks like is cyanosis. The people get blue around the lips, and they basically suffocate like cyanide poisoning. You would have to take a hundred of those lozenges to see any changes in methemoglobinemia. The other is low blood pressure. But you take too much nitric oxide, you'll see systemic vasodilation, and you'll see a drop in blood pressure. You'll get sick of it. You get lightheaded because you can't profuse the brain because of low blood pressure. Those are the only signs of toxicity based on the chemistry of nitric oxide. 

So the trick has been– how do you restore? Again, the keyword is restore. We don't want to give the body more than what it's used to seeing or what it would normally produce. And that's what we've learned over the past 20 years. How much nitric oxide to generate over a certain period of time to recapitulate it basically. The only way to do that is through a lozenge because we generate. If your body can't make nitric oxide, we do it for you. That lozenge is designed to have a resonant time of about six or seven minutes. You put it in your mouth. It's activated by your saliva in regenerating nitric oxide gas. And that nitric oxide is absorbed in the oral cavity. It's oxidized to nitrite. It's transported to bind to the glutathione and transported as an S-nitrosoglutathione. And that extends the biological activity from one millisecond out to hours. 

Again through research, we know what normal plasma levels of these biomarkers are. We know what normal salivary levels of these biomarkers are. We give back what the body's missing. It's no different than anything else. If you're low in vitamin D, what do you do? You take vitamin D. How do you know you have enough? Where do you get your blood labs drawn? If your vitamin D is 80, you're vital right on the spot. So keep doing what you're doing. 

Same thing with this. There's no clinical measure of nitric oxide. Unfortunately, there are no labs that you can tell, like vitamin D or cholesterol, or triglycerides. So what do we have to do? We have to test our saliva, which there are salivary test strips out there that I developed over 12 years ago. They can tell you what your nitric oxide levels are. Or the best measure is check your blood pressure. It's easy. It's not invasive and you know if your blood pressure's normal. The beauty of what we do is, for instance, my blood pressure runs about 116 over 68 or 72. So when I take a lozenge, it doesn't trump my blood pressure and that's called homeostasis. If your blood pressure's high, you take it and it normalizes it. If blood pressure is normal or low, you won't further reduce your blood pressure. So it's a very important safety aspect about what we do because we don't want to lower blood pressure more in people with already low blood pressure.

[01:25:18] Ashley James: Some people have low blood pressure. By the way, Dr. Wallach says that the first thing he goes to is the calcium deficiency, but that doesn't mean you eat more dairy. You want to make sure you're getting an absorbable form of calcium that is useful to the body. I have a family member who was fainting from standing up. He was bedridden just recently. He tries to stand up with a walker and immediately, his blood pressure drops so low that he is fainting. So I gave him the liquid calcium and multi-mineral from takeyoursupplements.com. I read about them and so many interviews. Within days, he's able to stand without fainting. And that's so cool. 

There are always other reasons that can cause low blood pressure, but for him, it's the first thing to try when you hear some good information from a holistic doctor. You try it and you get some results. I just love that. I'm so excited to get these lozenges. We used to be on for about seven years. We moved last year, but we have been drinking nitrites for seven years. There are high levels of nitrites in our well water. It wasn't high enough to cause Blue Baby Syndrome. That's what I was concerned about. When my son was a baby, I was concerned about that. It was naturally high in our area. There was no agricultural area and it was kind of weird. And I was concerned about it. 

My husband's blood pressure was really under control in those seven years. He was getting nitrites and one of the sources was from our well water. They would test it often and it was high. It's high normal but not dangerous, but still high. I thought to myself, that's interesting. Maybe think back to when we were cavemen and we're drinking water that naturally has nitrites in it, maybe because of the breakdown of stuff. One of the reasons it's in well water is the breakdown of vegetation and things like that. And that can be dangerously high and toxic because if you're getting unclean well water from the farmland, that leech to it. One of the sources that someone could get it from. So it's interesting. I'm excited to get these lozenges because I want to give it to my husband. Lately, his blood pressure has been creeping up, which can also be from stress. We're under high stress right now because of taking care of sick family members. I'm just really excited and I'm already on your website buying the lozenges right now. I'm very excited to get him on it and I will come back and share it with the listeners after my husband takes it in and let them know what happens with his blood pressure. So I'm going to take some too and then work out at the gym and I'm going to let everyone know what I felt. If I noticed a difference in my ability to keep going at the gym or if I gave up after five curl-ups. 

[01:28:43] Dr. Nathan Bryan: It involves science. We've learned a lot over the past 20 years and continue to pivot and improve. We've learned over the 20 years that nitric oxide is clinically important, but it's not a silver bullet. It's not an end-all, be-all, and cure-all. But what's clear is that your body cannot and will not heal or perform optimally unless you have sufficient nitric oxide being produced. Going back to what you said earlier about these mineral deficiencies, I've been in basic science for almost 25 years. What's clear to me is that people get sick for two weeks in two weeks only. It didn't matter if it was cancer, heart disease, Alzheimer's, or Diabetes. So the body is missing something that it needs, or it's exposed to something that it doesn't need. 

In that model, in that paradigm, there's no room for drug therapy. If you're deficient in the mineral, you'll get sick. If we supplement and give back what's missing, we remove any toxin, whether it's fluoride or herbicides or pesticides or EMF or infections from root canals. If we remove the source of exposure to toxins and give back what the body's missing, the body heals itself. That's the only way people are going to get better. It's not through drug therapy. It's not putting band-aids on and not getting to the root cause. So the end result of all that, whether you are toxic or your mineral deficient, leads to a loss of nitric oxide production. They reduce blood flow, increase inflammation, oxidative stress and immune dysfunction and that's the hallmark of every single chronic disease. 

[01:30:30] Ashley James: Fascinating. Do you have any information about cancer and nitric oxide?

[01:30:40] Dr. Nathan Bryan: When nitric oxide is known to regulate cell cycle and cell proliferation, this goes back to the 1940s, and this is called the Warburg effect that cancer cells only respire and proliferate in low oxygen, in low pH environment. So it's a mitochondrial disease. It's mitochondrial dysfunction. So it's typically caused by some toxins. So it got to remove the source– and this is what frustrates me about oncologists. It does not matter if it's breast cancer, prostate cancer, or brain cancer. They only have three tools– surgery, chemo, and radiation. The frustration is the oncologist never asked the patient, why did you have cancer? How can you treat something if you don't know why you got it? To throw into those three responses to every single cancer case that they see. Nobody's ever been cured of cancer from surgery, chemo, or radiation. It's never happened. 

If they put them in regression, it may extend their life, but it's never cured cancer. It's never in the history of the world that cancer has been cured with standard chemo, radiation, and surgery because they don't understand the etiology of cancer. What's poisoned the mitochondria to allow them to what's called anaerobic fermentation and to disrupt normal cellular metabolism. That's the root cause of cancer. We have to figure out what's poisoning the mitochondria. It's usually some toxins and usually, it's a toxin from some infections that you have in the body. Whether it's a brown section or whether it's bacterial on asymptomatic bacterial infection in root canals. We're finding most solid tumors can be traced back to an infection in a root canal tooth. So we have to remove the source of infection, extract the root canal teeth, clean up the infection, and then support the body so it can basically heal. Get some voltage, an oxygen increase, while pH increases oxygen delivery. So you do that partly through nitric oxide and then the body heals itself. It's really very clear to me. 

[01:32:57] Ashley James: I love it. I'm just so excited about what you're delivering today to the listeners and how it can help them. Those who are suffering from major diseases. Those who want to prevent major disease or want to reverse the disease or those who want to feel better. Wherever they are, they just want to feel better. This some very, very, very excited. So when we started taking lozenges, we started slow. I'm going to take it once a day and see how it goes. Then maybe once or twice a day and see how it goes. Is there anything about body weights, like a 100-pound woman and a 350-pound man taking different amounts?

[01:33:40] Dr. Nathan Bryan: Regarding what we do, whether it's in dietary supplements, the only thing we have to do is demonstrate safety. Obviously we can't make drug claims. But everything we do is tailored toward a 70 to an 80-kilogram person, which is 130 to 160-pounds human. And that's the benchmark. So that's how drugs are developed. So obviously, if you got a 60,70-pound kid, take half. If you're older than that, our total body volume is more than that. So the pharmacokinetics are going to be much different than a 120-pound person. 

But I think what we have nitric oxide and what we do in that lozenge, technology is nitric oxide over a certain period of time and people typically get the same response. So that doesn't mean that a 240-pound person should put two lozenges into their mouth at one time. I wouldn't recommend that. We found that one wasn't like for me. I'm 48 years old and the vascular age of a 28-year-old. I'm in pretty good health. I don't have any issues with blood pressure. Labs are pretty good, actually, very normal for a 48-year-old. So I take one lozenge a day because it gives me that support I need. But I try to eat and I go to the gym every day. I send an infrared sauna and every day. I'm in a hyperbaric chamber every night when I'm at home. I'm not at home pretty much because I travel a lot. 

So I do everything that my body needs to optimize nitric oxide production. So I don't need that much more health. Everybody's busy. People don't always eat a good diet, and certainly, most people don't have time or the discipline to go to the gym everyday and get modern physical exercise. So those are the people that need the most support. Not us that are health conscious and try to do the things. Watch what we eat and take on the discipline to do the right things even though it's hard work and very time-consuming to stay healthy. But for me, it's worth it because the last thing I want to do if you're unhealthy– our health is our greatest asset. We can't enjoy life if we don't have good health. It's worth the hard work, and your body will thank you for it.

[01:35:57] Ashley James: If you have paid good money to buy a house, you have to replace the roof every 10 years with one of those really cool roofs for every 40 years. You've made all this money and put all this effort into buying a house and paying off a mortgage. You're not going to let the roof rot. Then just completely destroy your investments and where you live. Your body is where you live. Yes, it's a pain in the butt to make lifestyle changes and make habit changes and make diet changes. 

I have a little brat inside me that she's like about six and she just wants, what she wants, what she wants. She wants to go to the drive-thru. She wants to eat all the junk they sell at the movie theater. Like she just wants what she wants, what she wants it and that's what she wants that dopamine spikes. She wants those feel-good chemicals that happen in the brain when she gets her way. She gets to eat fried foods, sugary, greasy, whatever kind of food. We all have that brat inside of us that is drug-addicted. Addicted to processed food that wants that rush. 

For some people, it's potato chips. For some people, it's fast food. For some people, it's alcohol, right? Alcohol is something I bet decreases nitric oxide production. So I'm just going to guess. Am I right? Does that have any effect on nitric oxide production? 

[01:37:24] Dr. Nathan Bryan: Well, it does but increasingly not. We published data probably 15 years ago. Moderate alcohol consumption is cardioprotective. So meaning that there are observational data that if you have a heart attack after one or two drinks, the heart suffers less injury from a heart attack than people who say they didn't have a drink. So mechanistically, we know that a moderate alcohol consumption upregulates some enzyme called alcohol dehydrogenase. It also causes an aldehyde dehydrogenase and extends the biological half-life of nitric oxide. 

That's moderate and it's called ethanol preconditioning. Again, there's a very narrow opportunity there to do that. So you can quickly overdo it and then you overburden the liver. You upregulate p450 enzymes and it leads to a number of problems. But moderate alcohol consumption is actually cardioprotective.

[01:38:22] Ashley James: You have those two glasses of wine and then have a heart attack. Can't you have two glasses of wine yesterday and have a heart attack right? Are you saying it's just after moderate alcohol consumption?

[01:38:38] Dr. Nathan Bryan: That's right. 

[01:38:40] Ashley James: Everyone's walking around with a glass of wine like I'm going to sip just in case, moderately protective of my heart. What's better is eating super clean, super healthy, and getting some good nitric oxide. So let's prevent damage to our heart by preventing heart disease in the first place. It's been so much fun having you on the show. I'm really excited to dive in and also you have this great book on your website. So when listeners go to your websites, it's very easy, it's very clean and not cluttered. It's n1o1.com. There's the cool skincare stuff. There are the little lozenges and then there's your book. So very simple. To rapid up, tell us about your book. What would we get into your book more than what we got today in this great interview? What more would we get if we got your book? Should we even get your book? Is your book is something we should dive into? 

[01:39:36] Dr. Nathan Bryan: I mean, this is in rapid-fire and this is 30 years of research and distilled down into 90 minutes. Most people learn through repetition. So the book is called Functional Nitric Oxide Nutrition. It basically distills down a very complex, complicated science into a story that's easily digested and easily understood. The plan and digestive. It's how you can use diet and lifestyle to restore your nitric oxide production. It's an easy read. It takes about an hour and 15,20 minutes, depending on how fast a reader you are. It's a good reference because you can go back and mark pages then over time, this is all going to make sense. So the point is simple strategies. Start to see changes in your own health and wellness. 

[01:40:32] Ashley James: Yes. I'm seeing nitric oxide now—you're like Joseph and the Technicolor Dreamcoat. You're way ahead of your time. That song is like he's way ahead of his time. These are early pioneering stages and think back to 100 years ago when they discover something about health. It's like– oh my gosh, there's a single vitamin C. It's amazing. We just discovered this but today, we take it for granted. We take vitamins for granted when they were first discover to prevent scurvy and all these other diseases. It's amazing. Vitamin C, it's revolutionary.

We take it for granted, but 100 years from now, everyone's going to be like– yes, don't get your nitric oxide check, what's wrong with you? You're completely low nitric oxide. Like– oh, you're low in vitamin C, get some even though this is not very new to us. So 100 years from now, no doubt, we need nitric oxide. This is something your lozenges are going to be on every shelf. It's going to be very needed and also common. Right now, it's not common because it's just the only groundbreaking field that's growing. I'm so excited to see the body of work as a science dive deeper into understanding human physiology and how to support the body in reversing and preventing disease. 

We can do so much of it from diet lifestyle, but also understanding their diet is compromised. It doesn't mean that they give up and go to McDonald's. Our diet is compromised because even no matter how healthy you eat, our farming practices over 100 years have messed up our food. So if you can grow your own food, it's great. If you can make a relationship with a farmer and that grows really clean, healthy, and re-mineralizes the soil and uses a nitrogen-based fertilizer. It's awesome. You can eat that food too. 

Check out the website of Dr. Nathan Bryan, which is n1o1.com. Use the coupon code LTH to get the awesome stuff. I'm going to share my results as I said and as I go forward using your stuff. Check out the book. I love the idea of real repetition, taking your 30 years of work and humility down to something that we can understand and absorb. And then take that to heart because this is the root. This is something so important. I don't want to overlook that if we can increase nitric oxide to healthy levels. We can have a healthy immune system, cardiovascular system, mitochondria, and healthy signaling in the body, and the list went on and on. So you guys are still discovering more benefits to it as well. Is there anything you'd like to say to wrap up today's interview?



[01:43:30] Dr. Nathan Bryan: No, I think just to touch on what you said, we're way ahead of our time. Nitric oxide is today where fish oil was 30 years ago. And now official is ubiquitous. Everybody knows. Most people supplement with it. But now, the science is very clear that your body cannot and will not heal without nitric oxide. So we have to start employing strategies and understand what are we doing on a daily basis that's disrupting our body's ability to produce nitric oxide. So we have to stop that and start doing the clinically proven things to promote it. I will share that I got an educational website. I'm not a big promoter of products and more on providing education and awareness. So you and your listeners can make informed decisions. So I've got an educational website called drnathansbryan.com. There's a six-minute video on there. I do a monthly blog. I try to provide some timely and practical tips that people can employ and hopefully, you can learn something. You can follow me on Instagram, Dr. Nathan S Bryan.com or LinkedIn.

[01:44:40] Ashley James: Love it. And of course, the links to everything you just mentioned will be in the show notes of today's podcast, learntruehealth.com or the description wherever you're listening from. It's been such a pleasure having you on the show. Please come back on the show when you have more breakthroughs. We'd love to be updated as you continue to innovate and dive into this. When your drug is full, all the testing is done, all these studies have been completed and it's now approved for FDA use. I'd love to also hear more stories about that. 

Again, I'm not a fan of drugs, but I'm a big fan of drugs that will save someone's life. I'd rather be on a drug alive. So if we can have saved your life with a drug, let's do everything we can to get your healthy again. Just do everything to get you healthy, so you don't need the drug. But I'm so glad that emergency medicine is available to us. It shouldn't be the only medicine we go. We don't want to wait until we get sick and then go to the emergency room. So let's do everything we can to prevent never having to go there in the first place. But still, when your drug is totally approved, in, and available in ERs. I'd love to have you back on the show to hear more about the studies, the success, and the results. Of course, with anything that you're innovating around this, please come back. We'd love to hear more. 

[01:45:57] Dr. Nathan Bryan: Thank you so much. 

[01:45:59] Ashley James: I hope you had a fantastic time listening to today's interview. Wasn't that mind-blowing? I look forward to the next few interviews because I have some more mind-blowing fantastic interviews in the pipeline. I want to make sure you know to go to Dr. Nathan Bryan's website and use the coupon code LTH as in Learn True Health for the amazing discount he's giving all the listeners. You can go there by going to n1o1.com. Look for the show notes of today's podcast learntruhealth.com to get all of the details of all the links for Dr. Nathan Bryan. Please come join the Facebook group if you haven't already. It's a very supportive group. We've got thousands of listeners there who love asking questions, answering them, and sharing their information, experiences, and testimonials. You can use the search function in the Facebook group. We've had the Facebook group for years. You can use the search function and dig through and read so many resources. There are so many wonderful resources in the Facebook group. And you might not know this, but you can go to learntruehealth.com, my website and use the search function there as well. So we're coming up on 500 episodes soon. 

We have a lot of resources there. You can read the transcripts of the interviews as well. Should you want to peruse through other topics. We cover everything from emotional health, mental health, spiritual health, energetic health, and physical health. Even episodes on lifestyle and improving lifestyle, improving building healthy habits that stick and decreasing anxiety. All kinds of wonderful topics to explore in learntruehealth.com. 

Thank you so much for being a listener. Thank you so much for sharing this podcast with those you love. My goal is to help as many people as possible to Learn True Health. Unfortunately, there is suffering that is not mandatory. Suffering is optional. That's why I want to help people who are suffering as I suffered for so many years because the doctors I went to didn't have the tools to help me. The doctors on my show, the holistic doctors, have the tools. They get the results. So I bring people on the show who get results that you don't need to suffer anymore. So your mom, your dad, your sister, your friends, and your children don't need to suffer anymore. 

And it's a matter of finding the information, finding the right doctors, and applying it to lives. And that's why I'm so grateful that you continue to share my podcasts with those you care about because together, we can help end suffering. So suffering shouldn't be mandatory. It should be optional. There's so much information out there. People have reversed Diabetes, reversed cancer, and reversed heart disease. People have reversed that they've suffered from reversed depression and addiction. They have done that. And we can help those you care about. We have the resources. So I suffered for so many years until I found holistic medicine and applied it to my life. I found the doctors that help and that's why I'm doing what I'm doing. We can take this information to those we care about and help them heal and help them no longer suffer. So let's end the suffering of those we care about. Continue to share this information. If you have any feedback and if you have any doctors you want me to interview that helped you, I love to hear from you. Come to join in the Facebook group and let me know. Come and feel free to email me at ashley@learntruehealth.com. We'd love to hear from you. Thank you so much. Enjoy and have a wonderful rest of the day.

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Ashley James

Health Coach, Podcast Creator, Homeschooling Mom, Passionate About God & Healing

Ashley James is a Holistic Health Coach, Podcaster, Rapid Anxiety Cessation Expert, and avid Whole Food Plant-Based Home Chef. Since 2005 Ashley has worked with clients to transform their lives as a Master Practitioner and Trainer of Neuro-linguistic Programming.

Her health struggles led her to study under the world’s top holistic doctors, where she reversed her type 2 diabetes, PCOS, infertility, chronic infections, and debilitating adrenal fatigue.

In 2016, Ashley launched her podcast Learn True Health with Ashley James to spread the TRUTH about health and healing. You no longer need to suffer; your body CAN and WILL heal itself when we give it what it needs and stop what is harming it!

The Learn True Health Podcast has been celebrated as one of the top holistic health shows today because of Ashley’s passion for extracting the right information from leading experts and doctors of holistic health and Naturopathic medicine


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